منابع مشابه
Dmd058354 1508..1513
Orally administered drugs may be metabolized by intestinal microbial enzymes before absorption into the blood. Accordingly, coadministration of drugs affecting the metabolic activities of gut microbes (e.g., antibiotics) may lead to drug-drug interactions (DDI). In this study, gut microbiota-mediated DDI were investigated by studying the pharmacokinetics of lovastatin in antibiotic-treated rats...
متن کاملBio013839 1490..1508
Here, we report that on six widely separated Scandinavian islands, the coal tit Parus ater has evolved morphologically in the direction of two absent competitors, the crested tit P. cristatus and the willow tit P.montanus, to the effect that it is up to 10% larger in linear dimensions than conspecifics on the adjacent Swedish mainland, where all three species coexist. The large size is genetica...
متن کاملAndrea Musacchio
refinements of this equipment. There was a direct analogy with the voltage clamp approach in nerve, but now length or force became the controlled parameter in place of voltage. This approach was applied in a quantitative study of the relation between the steady force produced by an active muscle fiber and its length: Huxley showed that force is proportional to overlap between the thick and thin...
متن کاملOp-molb150072 1567..1580
Persistent adaptive challenges are often met with the evolution of novel physiological traits. Although there are specific examples of single genes providing new physiological functions, studies on the origin of complex organ functions are lacking. One such derived set of complex functions is found in the Lepidopteran bursa copulatrix, an organ within the female reproductive tract that digests ...
متن کاملDmd063545 1572..1580
Intestinal bacteria have been shown to be important in regulating host intermediary metabolism and contributing to obesity. However, relatively less is known about the effect of intestinal bacteria on the expression of hepatic drug-processing genes in the host. This study characterizes the expression of hepatic drug-processing genes in germ-free (GF) mice using RNA-Seq. Total RNA were isolated ...
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ژورنال
عنوان ژورنال: Nexus Network Journal
سال: 2008
ISSN: 1590-5896,1522-4600
DOI: 10.1007/s00004-008-0066-1